The Boston Globe has a story of self-publishing success:
With a draft of her novel completed, Brunonia Barry of Salem wanted to find an audience. But instead of chasing after publishers - often a discouraging task for any new author - she and her husband took a different tack. They published "The Lace Reader" on their own.
more stories like thisThen something amazing happened: Buzz exploded around the book, both online and in stores, and mainstream publishers came calling. In October, a literary auction was held, and Barry sold the book, and a future one, for more than $2 million.
It is one of the biggest deals ever for a previously self-published first novel and a vivid example of how old publishing norms have changed. Self-publishing was once a consolation prize for a pipe-dreamer. But today it's possible for writers such as Christopher Paolini, author of the fantasy blockbuster "Eragon," Richard Paul Evans, author of the bestseller "The Christmas Box," and Zane, whose first three novels were self-published, to bypass publishers, then score lucrative contracts with them once their books are proved.
Before us self-publishers get too excited though, perhaps the most pertinent piece of information is on page two: Barry spent $50,000 in publishing and promoting the book...

Comments
Correction re Paolini
Paolini's parents are publishers. The old adage is true: it's not what you know, but who you know.